- addressing diabetes with pancreas organoids -
Maastricht – May 10, 2016 – The innovations introduced by LSFM4LIFE strengthen the leadership of Europe in the field of advanced therapies and, in particular, in cell-based therapies.
The goal of the new EU project LSFM4Life is the production of long-term renewing pancreas organoids for the cellular therapy of type 1 diabetes. The cause of this type of diabetes is a lack of insulin-producing beta-cells in the pancreatic islets. The rate of people affected by type 1 diabetes is rising every year and is increasing particularly amongst young children.
Pancreas organoids derived from adult pancreas stem cells are one of the most promising technologies for cellular and regenerative therapy. “LSFM4LIFE provides the unique chance to achieve something of significance for the patients, especially for children and their families.” says Francesco Pampaloni, co-applicant and scientific manager of LSFM4LIFE. “We formed a well-balanced blend of academia and industry partners, gathering a tremendous expertise. While insulin is the life-saving treatment of type 1 diabetes, LSFM4LIFE seeks a cure.”
PharmaCell is supporting the consortium with its expertise in the field of cell therapy manufacturing. “It is crucial for cell therapy developers to strategically think of the product and process development trajectory in front of them” says Nasser Sadr (Manager Process Development and Research, PharmaCell): “Too often brilliant ideas fail to translate into viable therapeutic approaches due to a naïve developmental approach. We are glad to participate in a consortium that brings early on together a broad panel of academic, clinical, and industrial experts, synergically working to maximize impact.”
The LSFM4LIFE project was granted within the Horizon2020 Program of the European Union after a competitive two-stage selection process. The project started with a kick-off meeting in Brussels on 9 February 2016 and will be funded for four years.
Establishing pancreas organoids for the therapy of T1D is an innovative process. Its accomplishment requires a critical mass of experts that is available at the European level. The consortium includes three top academic research groups from Frankfurt (Germany) Cambridge (UK) and Milan (Italy) as well as four small and medium-sized enterprises (SME) from Germany, France, The Netherlands and Switzerland.
Acknowledged experts from both academia and industry have multi-disciplinary expertise in the production of adult stem cell organoids, organ transplantation, good manufacturing practice (GMP) production of cellular therapeutic, biomimetic hydrogels, three-dimensional cell cultures and advanced microscopy.
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Soenke Brunswieck, PhD
Director Business Development
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